ED S. JESALVA, MD
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Psilocybin: Insights From A Psychiatrist For Depression

8/26/2025

11 Comments

 
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As a psychiatrist for depression and other mental illnesses, I see firsthand the struggles of my patients. While there are many FDA-approved pharmaceutical drugs and approved therapies for these conditions, I believe psilocybin also has potential as a therapeutic tool, especially for patients who may not have responded well to traditional treatments. Let’s take a look at this often-controversial subject.

What Is Psilocybin?

Psilocybin, often known as “magic mushrooms,” is a naturally occurring psychedelic compound found in some types of mushroom species. It is classified as a hallucinogen and has been used for centuries in spiritual and therapeutic practices.
When consumed, psilocybin is metabolized into psilocin in the body, which then binds to serotonin receptors in the brain. This interaction results in changes to perception, mood, and consciousness, often leading to visual and auditory hallucinations.​

A study at Washington University in St. Louis tracked changes in the brain before and after the use of psilocybin. The researchers found that a microdose of psilocybin had a profound effect on what is known as functional connectivity. This refers to how different regions in our brains communicate and work together to perform tasks or process information.
Essentially, it is postulated that small doses of psilocybin, given in controlled circumstances, might act as a sort of “reset” for our brains. Research suggests that psilocybin may boost our brain’s ability to reorganize and form new and healthier patterns of thought and behavior. It may help patients improve emotional processing as well as emotional regulation.

Is Psilocybin Legal?

Psilocybin remains illegal under federal law in the United States. Keep in mind, many states of legalized the use of marijuana, both for therapeutic and recreational use, yet this drug still remains illegal at the federal level.

Psilocybin is classified by the U.S. government as a Schedule I controlled substance under the Controlled Substances Act. In 2018, researchers at Johns Hopkins University, a world-renowned facility for medical research,  recommended that this drug be reclassified as a Schedule IV drug.

Schedule I drugs are those that the government has categorized as those with no currently acceptable medical uses and with a high potential for abuse. The schedule also includes drugs such as marijuana, LSD and heroin. Schedule IV drugs include drugs such as Xanax, Ambien, Valium and others that have accepted medical uses and a lower potential for abuse than drugs in Schedule I, II and III.

Keep in mind, these are categories developed by the government, and don’t necessarily reflect the opinions of all medical professionals, nor do they necessarily reflect the results of current scientific research.
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Despite the illegality at the federal level, several states and localities have enacted measures to decriminalize or legalize psilocybin for medical or therapeutic use, including:

  • Oregon: Oregon was the first state to legalize psilocybin for therapeutic use. Adults aged 21 and older may access psilocybin in licensed service centers under the supervision of trained professionals.
  • Colorado: In 2022, Colorado voters approved a measure to legalize psilocybin for therapeutic use in regulated settings.
  • New Mexico: In April 2025, New Mexico passed the Medical Psilocybin Act, legalizing psilocybin for medical use under a regulated program. However, this will not be fully implemented until 2028. 
Additionally, several cities in the United States have decriminalized psilocybin, meaning that law enforcement may treat offenses related to psilocybin as a low priority:

  • California: Cities including Oakland, Santa Cruz, San Francisco, Berkeley, and Eureka have decriminalized psilocybin, reducing penalties for possession. However, statewide laws still classify psilocybin as a controlled substance, and cultivation or distribution remains illegal. As a psychiatrist in Westlake Village, I am hopeful that Los Angeles and Ventura counties will eventually follow suit and decriminalize the psilocybin therapeutically.
  • Washington, D.C.: In 2020, Initiative 81 was passed, making the enforcement of laws against psilocybin a low priority for law enforcement.

Potential Therapeutic Uses for Psilocybin

For many years, researchers were unable to legally study psychedelics, but in the last few decades, we’ve been able to begin studying the impact that these substance might have on healthy individuals as well as those who needed help with specific issues, ranging from depression to PTSD to anxiety and even with various substance use disorders, such as smoking and alcoholism.

Johns Hopkins, the facility that in 2018 recommended reclassifying psilocybin from Schedule I to IV, launched a center for psychedelic research in 2019, and in 2021, the university was awarded the first federal grant from the National Institutes of Health to explore the impact of using psilocybin for tobacco addiction.

While Johns Hopkins is not the only institution studying psychedelics, their results have been very promising so far. For instance, some of their studies have shown that psilocybin can be an effective treatment for depression, including major depressive disorder and treatment resistant depression.

In one study, participants were given two doses of psilocybin two weeks apart. The results were very promising, as the participants saw large decreases in severity and symptoms of depression and, for many, the results were long-term, lasting a year after the treatment. While larger studies and clinical trials are needed, this is an excellent result, and, as a medical doctor and mental health professional, I have high hopes that further research will yield similar outcomes.
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As a psychiatrist for depression, as well as a psychiatrist for anxiety and PTSD, I believe that psilocybin has great potential for treating many mental health conditions. In addition to treating depression, it may be useful for treating anxiety, PTSD, OCD, and it’s been found to be highly beneficial for helping in end-of-life care, helping terminally ill patients cope with the fear and depression related to dying.

Who Should Avoid Psilocybin Therapy?

Again, it is important to note that psilocybin is only legal in a few areas, and, even in these areas, it is restricted to therapeutic use in controlled settings. While I do believe psilocybin potentially can benefit some people, this therapy is not suitable for individuals with certain conditions or situations, including:
  • Individuals with a history of psychosis or schizophrenia: Psilocybin can trigger or worsen psychotic episodes in those with a family or personal history of schizophrenia or related conditions. As a bipolar psychiatrist, I do not recommend this drug for patients with bipolar disorder, schizophrenia and other conditions that can cause psychosis.
  • People with severe personality disorders: Conditions such as borderline personality disorder or antisocial personality disorder may make it more difficult to process the intense emotions and experiences psilocybin can provoke. As a borderline personality disorder doctor, I don’t recommend psilocybin for these conditions.
  • Those with uncontrolled medical conditions: Individuals with unstable cardiovascular conditions (like heart disease) or severe epilepsy might be at higher risk due to the physiological effects of psychedelics.
  • Pregnant or breastfeeding women: While there is limited research on psilocybin’s effects during pregnancy or breastfeeding, it’s generally advised to avoid it due to potential risks to fetal development or infant health.
  • People currently taking certain medications: Psilocybin can interact with medications like antidepressants (especially SSRIs), antipsychotics, and blood pressure medications, possibly leading to adverse effects. For those on SSRIs, it is strongly recommended that you taper off these drugs before taking any type of psychedelic.
  • People with unrealistic expectations or insufficient psychological support: Psilocybin therapy often involves intense emotional experiences that require proper guidance. Those who aren't prepared mentally or don’t have access to professional support may struggle with the process. 

What About Addiction?

As an addiction psychiatrist, I have concerns that some people with a history of substance abuse may be more likely to misuse psilocybin, even if it’s used in a therapeutic setting. However, while I have concerns, there have been four clinical trials that showed psilocybin seemed to benefit the subjects.

Keep in mind, these are very small, limited studies that only included individuals with alcohol and tobacco use disorders.  The psilocybin also was combined with some form of psychotherapy, such as talk therapy or cognitive behavioral therapy. With any type of medicine, adding a therapy component tends to increase the success of treatment significantly.
​

If you are struggling with a substance use disorder, other types of treatments might be a better option than psilocybin for some people. If you are struggling with addiction, please contact me, and we will create a treatment plan that helps guide you into a successful recovery.

Potential Side Effects

While you likely have heard about the potential for hallucinations, in non-therapeutic doses and non-therapeutic settings, psilocybin may cause some uncomfortable or even dangerous side effects such as anxiety and paranoia, mood swings, confusion and difficulty concentrating or thinking rationally.
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Psilocybin also may cause nausea and vomiting, increased heart rate, increased blood pressure, muscle weakness and dizziness. When taken in non-therapeutic doses, it also can cause a “bad trip,” which might include high levels of fear and even panic attacks, and it can be difficult to process these emotions in an altered state. 

Final Thoughts

When we talk about the benefits of psilocybin, it’s important to remember that this drug was given in small doses in a safe, monitored setting. While I do believe that psilocybin has great potential to treat depression, PTSD and other illnesses, I also believe this drug needs to be given in a controlled setting with purpose and intent, just as we do when we provide ketamine treatments.
 
I am hopeful that more areas in the country will decriminalize its use and that larger studies will be done, as I believe the results will offer great hope to many people struggling with mental health disorders, especially for those who have not responded to traditional medications and therapies.
 
As a psychiatrist for depression, I can provide you with a myriad of treatment options, including more unique treatments such as using Auvelity, which I wrote about in my last blog post. This is a pharmaceutical drug that, in some ways, mimics what psilocybin can do, working as a type of reset for our brain. We also have options such as nasal esketamine and Transcranial Magnetic Stimulation, or TMS.  
 
If you are struggling with depression, anxiety, PTSD or other mental health issues, please contact me at any time to schedule a consultation. I work as a psychiatrist in Westlake Village, and serve clients in Thousand Oaks, Agoura Hills, Simi Valley and other nearby cities. We can work together to develop a treatment plan that addresses all of the issues you are facing and help you enjoy a healthier and happier life. 
11 Comments

Borderline Personality Disorder: Doctor Advice & Tips

9/20/2023

10 Comments

 
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It’s estimated that as many as five million Americans have borderline personality disorder, although that number could be higher, as many people with this condition go undiagnosed and untreated. As a borderline personality disorder doctor, I know that this mental health condition is often misunderstood and I also know that this disorder can be treated successfully, despite myths to the contrary. Let’s take a look at this mental health condition and some of the current treatment options.

​What Is Borderline Personality Disorder?

In the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which is produced by the American Psychiatric Association, borderline personality disorder is listed among 10 distinct personality disorders.
 
In general, a person with a “personality disorder” will experience different patterns of thought than most people. This includes how they perceive themselves as well as others, and how they respond and relate to other people. These disorders also affect behavior and emotional response. Most importantly, these disorders often cause distress and problems with daily life and relationships.
​ 
Borderline Personality Disorder (BPD) is characterized by a pattern of unstable relationships, self-image, and emotions. People with BPD often have difficulties regulating their emotions and thoughts, suffer from severe mood swings and they may exhibit impulsive and reckless behavior. Here are the primary symptoms of borderline personality disorder:
  • Fear of Abandonment: People with BPD often fear being abandoned or left alone. Even something as innocuous as a loved one arriving home late can trigger intense fear. This can result in frantic efforts to keep the other person close.
  • Unstable Relationships: Individuals with BPD tend to have relationships that are intense and short-lived. They may fall in love quickly, but their idealization of others can quickly shift to devaluation.
  • Unclear or Shifting Self-Image: People with BPD might frequently change their self-image, goals, values, or even their career plans. They may view themselves as evil or bad, and sometimes they may feel as if they don't exist at all.
  • Impulsive Behaviors: Engaging in potentially harmful activities such as substance abuse, binge eating, reckless driving, or spending sprees can be common among those with BPD.
  • Self-Harming Behavior: Suicidal behavior or threats and self-harm, like cutting, are potential symptoms. These distressing actions often result from feelings of emptiness and boredom, or as a way to cope with intense emotions.
  • Extreme Emotional Swings: Unstable emotions and moods are common in people with BPD. While they can be joyful and loving one moment, they can become irritable or anxious the next, often lasting a few hours to a few days.
  • Chronic Feelings of Emptiness: Individuals with BPD often express feeling empty which can be distressing.
  • Explosive Anger: They may struggle with intense anger, often finding it challenging to control. This can result in shouting, throwing things, or becoming completely consumed by rage.
  • Feeling Suspicious or Out of Touch with Reality: Periods of paranoia related to stress or feeling disconnected from oneself or reality, known as dissociation, can occur.

As a psychiatrist in Westlake Village who often treats patients with BPD, I find that It's important to note that BPD is a complex disorder, and not everyone with BPD will exhibit all these symptoms. The severity and manifestation of symptoms can vary widely among individuals. If someone suspects they or someone they know may have BPD, it's essential to seek a professional diagnosis and appropriate treatment from a borderline personality disorder doctor, such as a psychiatrist or psychologist (or ideally, both). 

​Common Myths About This Disorder

Borderline personality disorder (BPD) is a complex mental health condition that is often misunderstood. Several myths and misconceptions surround BPD, which can contribute to stigma and make it harder for those with the disorder to seek help and support.
 
Myth: People with BPD are just seeking attention.
Fact: BPD is a legitimate mental health disorder with specific symptoms. It's not about seeking attention but rather a struggle with emotional regulation, self-image, and interpersonal relationships.

​Myth: BPD isn't a real psychiatric disorder.
Fact: As stated above, BPD is recognized by major medical institutions and diagnostic manuals, such as the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The Americans With Disability (ADA) Act also recognizes BPD as a disability.
 
Myth: Only women have BPD.
Fact: While BPD is diagnosed more frequently in women, men can and do suffer from it as well. The presentation of symptoms might differ between genders, leading to potential underdiagnosis in men.
 
Myth: People with BPD are manipulative.
Fact: While individuals with BPD might exhibit behaviors that seem manipulative, it's essential to understand these actions often stem from an intense fear of abandonment or rejection rather than a desire to manipulate others.
 
Myth: BPD is a result of bad parenting.
Fact: While childhood trauma or neglect can be risk factors, BPD's exact cause is unknown. It's believed to result from a combination of genetic, environmental, and neurological factors.
 
Myth: BPD and bipolar disorder are the same.
Fact: While both disorders involve mood disturbances, they are distinct conditions. BPD primarily affects interpersonal relationships and self-image, while bipolar disorder affects mood in terms of mania and depression.
 
Myth: People with BPD are violent and dangerous.
Fact: While some individuals with BPD might have aggressive outbursts, it doesn't mean they are inherently violent. Often, the anger is directed inward, leading to self-harm rather than outward violence. Self-harm, such as cutting, and suicidal thoughts and suicidal attempts are extremely common with BPD.
 
Myth: Individuals with BPD can't have healthy relationships.
Fact: While interpersonal relationships can be challenging for those with BPD, with therapy and support, many can and do have fulfilling, healthy relationships.
 
Myth: People with BPD are just being dramatic.
Fact: The emotions and reactions of someone with BPD are very real to them. Labeling them as "dramatic" invalidates their experiences and struggles.
Understanding and dispelling these myths is crucial for reducing stigma and providing appropriate support and care to those with BPD.
 
Myth: BPD is untreatable.
Fact: BPD is treatable, and many individuals with the disorder experience symptom relief and improved quality of life with appropriate therapy, such as Dialectical Behavior Therapy (DBT).

​Treatment Options

​Psychotherapy is the most common treatment option for people with BPD. There are several different types of psychotherapy that a borderline personality disorder doctor might suggest including dialectical behavior therapy (DBT), mentalization-based therapy (MBT), schema-focused therapy and other types of talk therapy.
 
While there are no FDA-approved medications available specifically to treat BPD, a borderline personality disorder doctor (a psychiatrist) can prescribe medications to treat some issues related to this disorder, such as antidepressants, mood stabilizers or antipsychotic drugs. There is also some evidence to suggest that ketamine might be a treatment option to consider.
 
Ketamine’s original purpose was as an anesthetic, but eventually, it was found to have a positive effect on reducing suicidal ideation as well as in patients with treatment-resistant depression. Ketamine must be administered in a doctor’s office; it cannot be used at home like other types of psychiatric drugs. However, for many patients, only a few treatments might be necessary to achieve a significant lessening of symptoms.
 
In general, the best approach with any mental health disorder is a combination approach that includes talk therapy and, possibly, medication. A therapist or psychologist can help with talk therapy, and a psychiatrist can help with both diagnosis and medication management. As a psychiatrist also is a medical doctor, they also can consider whether any physical issues might be contributing to your mental health issues.
 
In many cases, a person with BPD also will have a co-occurring disorder, such as anxiety, depression, an eating disorder, addiction or another type of mental illness. Your care team must address all of the issues you are facing for the treatment to be successful.
 
I find that many of my patients suffer from multiple mental health disorders and it’s crucial to dive deep and find a diagnosis and treatment plan that accounts for all of these issues. I recommend finding mental health professionals who specialize in personality and mood disorders to ensure that all of your needs are being met.
 
Borderline personality disorder can be overwhelming for patients, as well as friends and family. I highly recommend friends and family members learn all that they can about this disorder and how to help a loved one with this condition. Talk therapy also can be a helpful outlet for loved ones. This helps you discuss worries, hopes, and frustrations in a safe place and find strategies to help your loved one.
 
For patients, maintaining consistent therapy sessions is crucial. Opting for doctors who provide teletherapy or telepsychiatry is an excellent option. This allows you to keep a consistent therapy regimen even if you are away from home or unable to drive to an appointment, etc. A virtual psychiatrist or psychologist treat borderline personality disorder from anywhere you have an internet connection.
 
For some patients, skipping the occasional therapy session isn’t always a problem. However, for people with borderline personality disorder, consistency is crucial and helpful, so an online psychiatrist or therapist can be a good option.
 
I also recommend keeping life as simple as possible, maintaining a daily schedule that includes exercise, a healthy diet, a good sleep schedule and some mindfulness exercises, along with techniques you learn in therapy. Keeping a mood diary also can help you understand what types of events trigger emotional responses and help you to see these situations in a more detached way.
 
For instance, you might look through your mood journal and notice that certain situations consistently trigger feelings of fear, rejection or abandonment. You can discuss these situations with your therapist and come up with strategies that help you work through these issues. 
 
BDT is a complex mental health condition, but it is absolutely not untreatable. I firmly believe that with consistent treatment people with BDT can enjoy happier, more successful lives and see a significant reduction in symptoms. The key is to seek treatment and stay consistent with therapy and medications.
 
Despite what you may believe about yourself – you are a worthy human being, and you deserve to have a better life. Not one of us humans is perfect, and we all must work to become the best versions of ourselves. With BPD, it can be tough because you are struggling with a mental health disorder and that’s not your fault, but it’s not impossible to treat and help is out there.
 
If you are searching for a psychiatrist in Westlake Village, I treat patients in person from all over the Los Angeles area. If you live outside of this area or prefer telepsychiatry, I can provide diagnosis and treatment plans via telepsychiatry. In addition to BPD, I also work as an ADHD psychiatrist, addiction psychiatrist, and bipolar psychiatrist and treat anxiety, depression, eating disorders and many other mental health conditions. Give me a call today and let’s get you on a path toward wellness and a better life!
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    Author

    Dr Jesalva is a psychiatrist.  He is in private practice in Thousand Oaks, CA since 1989.  He successfully treats very challenging patients with varying co-occurring disorders with medications.
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